长链非编码RNA对治疗耐药性的调控
Long non-coding RNAs regulation of therapeutic resistance.
作者信息
Tsang Susan, Patel Tajhal, Yustein Jason T
机构信息
Integrative Molecular and Biomedical Sciences Program, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Cancer Drug Resist. 2019 Sep 19;2(3):550-567. doi: 10.20517/cdr.2019.58. eCollection 2019.
Non-protein coding RNAs have emerged as a regulator of cell signaling and cancer progression through regulation of cell proliferation, metastatic burden, and cancer stem cell capacity. A subtype of non-protein coding RNA is long non-protein coding RNA (lncRNA). Besides their aforementioned roles in cancer cell biology, dysregulation of lncRNAs contribute to resistance to therapeutic treatments. A couple of important therapeutic classes are chemotherapy and targeted/hormone therapies. This review highlights the variety of malignancies affected by lncRNA dysregulation and the underlying mechanism causing therapeutic resistance.
非蛋白质编码RNA已成为细胞信号传导和癌症进展的调节因子，通过调节细胞增殖、转移负担和癌症干细胞能力来发挥作用。非蛋白质编码RNA的一个亚型是长链非蛋白质编码RNA（lncRNA）。除了在癌细胞生物学中的上述作用外，lncRNA的失调还会导致对治疗的抗性。一些重要的治疗类别包括化疗和靶向/激素疗法。本综述强调了受lncRNA失调影响的各种恶性肿瘤以及导致治疗抗性的潜在机制。
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