对 BNT162b2 mRNA 疫苗的免疫反应的持久性。
Durability of immune responses to the BNT162b2 mRNA vaccine.
机构信息
Department of Pediatrics, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA.
Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
出版信息
Med. 2022 Jan 14;3(1):25-27. doi: 10.1016/j.medj.2021.12.005.
Abstract
Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination.
摘要
接种第二剂辉瑞-生物科技 mRNA 疫苗 6 个月后，针对该疫苗的抗体反应明显减弱。
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本文引用的文献
1
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N Engl J Med. 2021 Dec 9;385(24):e85. doi: 10.1056/NEJMoa2114228. Epub 2021 Oct 27.
2
Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months.
N Engl J Med. 2021 Dec 9;385(24):e84. doi: 10.1056/NEJMoa2114583. Epub 2021 Oct 6.
3
Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants.
Science. 2021 Sep 17;373(6561):1372-1377. doi: 10.1126/science.abj4176. Epub 2021 Aug 13.
4
Systems vaccinology of the BNT162b2 mRNA vaccine in humans.
Nature. 2021 Aug;596(7872):410-416. doi: 10.1038/s41586-021-03791-x. Epub 2021 Jul 12.
5
Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells.
Cell Rep Med. 2021 Jul 20;2(7):100354. doi: 10.1016/j.xcrm.2021.100354. Epub 2021 Jul 3.
6
Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19.
N Engl J Med. 2021 Jun 10;384(23):2259-2261. doi: 10.1056/NEJMc2103916. Epub 2021 Apr 6.
7
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.
Cell. 2021 Apr 29;184(9):2384-2393.e12. doi: 10.1016/j.cell.2021.03.036. Epub 2021 Mar 20.
8
Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS-CoV-2 Neutralizing Antibodies.
Curr Protoc Immunol. 2020 Dec;131(1):e116. doi: 10.1002/cpim.116.
9
Heterogeneity and longevity of antibody memory to viruses and vaccines.
PLoS Biol. 2018 Aug 10;16(8):e2006601. doi: 10.1371/journal.pbio.2006601. eCollection 2018 Aug.
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