癌症中的 PI3K/AKT 信号通路：分子机制和可能的治疗干预措施。
The PI3K/AKT signaling pathway in cancer: Molecular mechanisms and possible therapeutic interventions.
机构信息
Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
出版信息
Exp Mol Pathol. 2022 Aug;127:104787. doi: 10.1016/j.yexmp.2022.104787. Epub 2022 May 27.
The human body consists of countless cells with the possibility of excessive and uncontrolled proliferation under certain dysregulated circumstances that could cause abnormal states such as cancer. Phosphatidylinositol 3 kinase (PI3K) and its downstream target, Protein kinase B or AKT, play a critical role in cell survival, proliferation, differentiation, migration, and metabolism. Research studies have examined the aberrant expression of signaling molecules that regulate PI3K/AKT pathway with the purpose of target discovery. The present review aims to recapitulate the relationship between the PI3K/AKT signaling pathway and factors contributing to initiation and development of various cancers. In addition, therapeutic interventions regulating this signaling pathway have been summarized.
人体由无数细胞组成，在某些失调情况下，这些细胞可能会过度且不受控制地增殖，从而导致异常状态，如癌症。磷脂酰肌醇 3 激酶（PI3K）及其下游靶蛋白，蛋白激酶 B 或 AKT，在细胞存活、增殖、分化、迁移和代谢中发挥着关键作用。研究已经研究了调节 PI3K/AKT 通路的信号分子的异常表达，目的是发现靶点。本综述旨在概括 PI3K/AKT 信号通路与导致各种癌症发生和发展的因素之间的关系。此外，还总结了调节该信号通路的治疗干预措施。
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