婴儿前列腺横纹肌肉瘤：一项诊断和治疗挑战。

Infant prostatic Rhabdomyosarcoma: A diagnostic and therapeutic challenge.

作者信息

Dhanji Sohail, Borregales Leonardo D, Janzen Nicolette K, Godoy Guilherme, Fuller Maren Y, Au Jason K

机构信息

The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical School, United States.

Texas Children's Hospital, United States.

出版信息

Urol Case Rep. 2022 May 13;43:102116. doi: 10.1016/j.eucr.2022.102116. eCollection 2022 Jul.

DOI:10.1016/j.eucr.2022.102116

PMID:35646598

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9133547/

Abstract

The following case report describes a case of prostatic rhabdomyosarcoma in a 6-month-old male who presented with urinary retention and constipation. MRI showed a prostatic mass that was displacing the rectum and bladder, leading to bladder outlet obstruction. A suprapubic tube was placed for urinary diversion and a transvesical approach was used for tissue diagnosis. Biopsy confirmed the diagnosis of prostatic rhabdomyosarcoma. Patient underwent chemotherapy regiment with VAC (vincristine, actinomycin D and cyclophosphamide) and subsequently ifosfamide and doxorubicin. Eventually, due to tumor progression, the patient underwent a radical cystoprostatectomy with pelvic lymph node dissection and ileal conduit.

摘要

以下病例报告描述了一名6个月大男性的前列腺横纹肌肉瘤病例，该患儿表现为尿潴留和便秘。磁共振成像（MRI）显示前列腺肿物，该肿物使直肠和膀胱移位，导致膀胱出口梗阻。放置耻骨上造瘘管进行尿液改道，并采用经膀胱途径进行组织诊断。活检确诊为前列腺横纹肌肉瘤。患者接受了VAC（长春新碱、放线菌素D和环磷酰胺）化疗方案，随后接受异环磷酰胺和阿霉素化疗。最终，由于肿瘤进展，患者接受了根治性膀胱前列腺切除术、盆腔淋巴结清扫术及回肠代膀胱术。