经典中药桃红四物汤治疗冠心病的研究进展。
Research progress on classical traditional Chinese medicine Taohong Siwu decoction in the treatment of coronary heart disease.
机构信息
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shangdong Province 250355, China; Shandong Co-Innovation Center of Classic TCM Formula, Shandong University of Traditional Chinese Medicine, Jinan, Shangdong Province 250355, China.
School of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shangdong Province 250355, China.
出版信息
Biomed Pharmacother. 2022 Aug;152:113249. doi: 10.1016/j.biopha.2022.113249. Epub 2022 Jun 13.
The pathogenesis of coronary heart disease is closely related to blood stasis. Taohong Siwu decoction (THSW for short) is one of the most widely used prescriptions for activating blood and removing stasis. Clinical research has confirmed its curative effect on coronary heart disease. However, its underlying mechanism remains unclear. Therefore, this paper reviewed the clinical efficacy of THSW and determine its effective components based on a comprehensive literature review. Furthermore, the core components and targets of THSW in treating coronary heart disease using molecular docking were verified, and the interaction sites were predicted to construct a theoretical basis for the clinical application of THSW.
冠心病的发病机制与血瘀密切相关。桃红四物汤（THSW）是最常用的活血化瘀方剂之一。临床研究已证实其对冠心病的疗效。然而，其作用机制尚不清楚。因此，本文通过全面的文献复习，综述了 THSW 的临床疗效及其有效成分。此外，还采用分子对接技术验证了 THSW 治疗冠心病的核心成分和靶点，并预测了相互作用位点，为 THSW 的临床应用构建了理论基础。
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