68Ga-FAPI-46 和 18F-FDG 在晚期转移性胰腺癌中的应用。
68 Ga-FAPI-46 and 18 F-FDG in Advanced Metastatic Pancreatic Cancer.
机构信息
From the Khatam PET/CT Center.
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Clin Nucl Med. 2022 Oct 1;47(10):e666-e669. doi: 10.1097/RLU.0000000000004316. Epub 2022 Jun 18.
Recently imaging with new PET radiotracers that act as fibroblast activation protein inhibitors (FAPIs) showed promising results in oncology and even nononcology imaging. Here we report a case of advanced pancreatic adenocarcinoma, imaged with both 18 F-FDG and 68 Ga-FAPI-46 PET/CT scans. The result indicated that imaging with 68 Ga-FAPI-46 showed significant improvement in detection of metastases as well as local malignancy recurrence. Moreover, the intensity and SUVs of the lesions were higher in 68 Ga-FAPI-46 scan compared with 18 F-FDG.
最近，使用新型的正电子发射断层扫描（PET）放射性示踪剂作为成纤维细胞活化蛋白抑制剂（FAPI）进行成像，在肿瘤学甚至非肿瘤学成像中显示出了有前景的结果。在这里，我们报告了一例晚期胰腺腺癌的病例，该病例同时进行了 18 F-FDG 和 68 Ga-FAPI-46 PET/CT 扫描。结果表明，使用 68 Ga-FAPI-46 进行成像在检测转移和局部恶性肿瘤复发方面有显著改善。此外，与 18 F-FDG 相比，68 Ga-FAPI-46 扫描的病变强度和 SUV 值更高。
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