1990 - 2019年中国乙肝病毒和丙肝病毒感染疾病负担的趋势

Trends in the disease burden of HBV and HCV infection in China from 1990-2019.

作者信息

Yue Tingting, Zhang Quanquan, Cai Ting, Xu Ming, Zhu Haizhen, Pourkarim Mahmoud Reza, De Clercq Erik, Li Guangdi

机构信息

Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Hunan, China.

Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Hunan, China.

出版信息

Int J Infect Dis. 2022 Sep;122:476-485. doi: 10.1016/j.ijid.2022.06.017. Epub 2022 Jun 17.

DOI:10.1016/j.ijid.2022.06.017

PMID:35724827

Abstract

OBJECTIVES

This study aimed to reveal the 30-year dynamics of hepatitis B virus (HBV) and hepatitis C virus (HCV) disease burden in China from 1990-2019.

METHODS

HBV/HCV data were retrieved from the Global Burden of Disease database. Joinpoint regression was used to examine temporal trends. Age-period-cohort models were applied to evaluate effects of patient age, period, and cohort on HBV/HCV-associated mortality and incidences.

RESULTS

A dramatic decrease in the disease burden of HBV was found from 1990-2019, but the disease burden of HCV has remained stable since 2000. Patient age, period, and cohort exerted a significant effect on the diseases burden of HBV and HCV infection. Compared with women, men had a higher risk of HBV/HCV infections as well as HBV/HCV-associated mortality and liver cancer. Overweight, alcohol, tobacco, and drug use were important risk factors associated with HBV/HCV-associated liver cancer. The incidences of HBV- and HCV-associated liver cancer from 2019-2044 are expected to decrease by 39.4% and 33.3%, respectively.

CONCLUSION

The disease burden of HBV/HCV infection has decreased in China over the past 30 years, but HBV incidences remain high, especially in men. Effective management of HBV and HCV infections is still needed for high-risk populations.

摘要

目的

本研究旨在揭示1990 - 2019年中国乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）疾病负担的30年动态变化。

方法

从全球疾病负担数据库中检索HBV/HCV数据。采用Joinpoint回归分析时间趋势。应用年龄 - 时期 - 队列模型评估患者年龄、时期和队列对HBV/HCV相关死亡率和发病率的影响。

结果

1990 - 2019年期间发现HBV疾病负担显著下降，但自2000年以来HCV疾病负担一直保持稳定。患者年龄、时期和队列对HBV和HCV感染的疾病负担有显著影响。与女性相比，男性感染HBV/HCV以及发生HBV/HCV相关死亡率和肝癌的风险更高。超重、饮酒、吸烟和吸毒是与HBV/HCV相关肝癌相关的重要危险因素。预计从2019年到2044年，HBV和HCV相关肝癌的发病率将分别下降39.4%和33.3%。