长链非编码 RNA 在肿瘤代谢重编程和免疫微环境重塑中的作用。
LncRNAs in tumor metabolic reprogramming and immune microenvironment remodeling.
机构信息
MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China; Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang, 310058, China.
MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China; Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang, 310058, China; Breast Center of the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China; International School of Medicine, International Institutes of Medicine, The 4th Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang, 322000, China; ZJU-QILU Joint Research Institute, Hangzhou, Zhejiang, 310058, China.
出版信息
Cancer Lett. 2022 Sep 1;543:215798. doi: 10.1016/j.canlet.2022.215798. Epub 2022 Jun 20.
Evidence accumulated over the past decade has verified that long non-coding RNAs (lncRNAs) exert important functions in multiple cell programs. As a novel class of cellular regulatory molecules, lncRNAs interact with different molecules, such as DNA, RNA or proteins, depending on their subcellular distribution, to modulate gene transcription and kinase cascades. It has been widely clarified that lncRNAs play important roles in modulating metabolic reprogramming and reshaping the immune landscape and serve as hinges bridging tumor metabolism and anti-tumor immunity. Given these facts, lncRNAs, as putative regulators of tumor initiation and progression, have attracted extensive attention in recent years. In this review, we summarized the current research progress on the role of lncRNAs in tumor metabolic reprogramming and tumor-immune microenvironment remodeling, and conclude with our laboratory's contributions in advancing the clinical applications of lncRNAs.
在过去的十年中，积累的证据已经证实，长非编码 RNA（lncRNA）在多种细胞程序中发挥重要功能。作为一类新型的细胞调节分子，lncRNA 根据其亚细胞分布与不同的分子（如 DNA、RNA 或蛋白质）相互作用，以调节基因转录和激酶级联。已经广泛阐明，lncRNA 在调节代谢重编程和重塑免疫景观方面发挥着重要作用，并作为连接肿瘤代谢和抗肿瘤免疫的枢纽。鉴于这些事实，lncRNA 作为肿瘤发生和进展的潜在调节剂，近年来引起了广泛关注。在这篇综述中，我们总结了 lncRNA 在肿瘤代谢重编程和肿瘤免疫微环境重塑中的作用的最新研究进展，并总结了我们实验室在推进 lncRNA 的临床应用方面的贡献。
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