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电子束放射治疗中的非靶区和野外剂量

Nontarget and Out-of-Field Doses from Electron Beam Radiotherapy.

作者信息

Matuszak Natalia, Kruszyna-Mochalska Marta, Skrobala Agnieszka, Ryczkowski Adam, Romanski Piotr, Piotrowski Igor, Kulcenty Katarzyna, Suchorska Wiktoria Maria, Malicki Julian

机构信息

Department of Electroradiology, Poznan University of Medical Sciences, 61-866 Poznan, Poland.

Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, 61-866 Poznan, Poland.

出版信息

Life (Basel). 2022 Jun 8;12(6):858. doi: 10.3390/life12060858.

Abstract

In clinical radiotherapy, the most important aspects are the dose distribution in the target volume and healthy organs, including out-of-field doses in the body. Compared to photon beam radiation, dose distribution in electron beam radiotherapy has received much less attention, mainly due to the limited range of electrons in tissues. However, given the growing use of electron intraoperative radiotherapy and FLASH, further study is needed. Therefore, in this study, we determined out-of-field doses from an electron beam in a phantom model using two dosimetric detectors (diode E and cylindrical Farmer-type ionizing chamber) for electron energies of 6 MeV, 9 MeV and 12 MeV. We found a clear decrease in out-of-field doses as the distance from the field edge and depth increased. The out-of-field doses measured with the diode E were lower than those measured with the Farmer-type ionization chamber at each depth and for each electron energy level. The out-of-field doses increased when higher energy megavoltage electron beams were used (except for 9 MeV). The out-of-field doses at shallow depths (1 or 2 cm) declined rapidly up to a distance of 3 cm from the field edge. This study provides valuable data on the deposition of radiation energy from electron beams outside the irradiation field.

摘要

在临床放射治疗中,最重要的方面是靶区和健康器官内的剂量分布,包括体内射野外剂量。与光子束辐射相比,电子束放射治疗中的剂量分布受到的关注要少得多,主要是因为电子在组织中的射程有限。然而,鉴于电子术中放射治疗和FLASH的使用日益增加,需要进一步研究。因此,在本研究中,我们使用两种剂量探测器(二极管E和圆柱形Farmer型电离室),在体模模型中测定了6 MeV、9 MeV和12 MeV电子能量下电子束的射野外剂量。我们发现,随着离射野边缘的距离和深度增加,射野外剂量明显降低。在每个深度和每个电子能量水平下,用二极管E测量的射野外剂量低于用Farmer型电离室测量的剂量。当使用更高能量的兆伏级电子束时(9 MeV除外),射野外剂量增加。在浅深度(1或2 cm)处,射野外剂量在离射野边缘3 cm的距离内迅速下降。本研究提供了关于照射野外电子束辐射能量沉积的宝贵数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b183/9225003/32ca423bd5cf/life-12-00858-g001.jpg

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