体外皮肤模型在辐射暴露方面的组学潜力。
-Omics potential of in vitro skin models for radiation exposure.
机构信息
Biosecurity and Public Health Group, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
Bioenergy and Biome Sciences Group, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
出版信息
Cell Mol Life Sci. 2022 Jul 1;79(7):390. doi: 10.1007/s00018-022-04394-z.
There is a growing need to uncover biomarkers of ionizing radiation exposure that leads to a better understanding of how exposures take place, including dose type, rate, and time since exposure. As one of the first organs to be exposed to external sources of ionizing radiation, skin is uniquely positioned in terms of model systems for radiation exposure study. The simultaneous evolution of both MS-based -omics studies, as well as in vitro 3D skin models, has created the ability to develop a far more holistic understanding of how ionizing radiation affects the many interconnected biomolecular processes that occur in human skin. However, there are a limited number of studies describing the biomolecular consequences of low-dose ionizing radiation to the skin. This review will seek to explore the current state-of-the-art technology in terms of in vitro 3D skin models, as well as track the trajectory of MS-based -omics techniques and their application to ionizing radiation research, specifically, the search for biomarkers within the low-dose range.
越来越需要发现与电离辐射暴露相关的生物标志物，以便更好地了解暴露的发生方式，包括剂量类型、剂量率和暴露时间。皮肤是最早受到外部电离辐射源暴露的器官之一，因此在辐射暴露研究的模型系统方面具有独特的地位。基于 MS 的组学研究以及体外 3D 皮肤模型的同时发展，使得我们能够更全面地了解电离辐射如何影响发生在人类皮肤中的许多相互关联的生物分子过程。然而，描述低剂量电离辐射对皮肤的生物分子影响的研究数量有限。本文综述将探讨体外 3D 皮肤模型的最新技术现状，并跟踪基于 MS 的组学技术及其在电离辐射研究中的应用轨迹，特别是在低剂量范围内寻找生物标志物。
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