通过靶向细胞表面 GRP78 根除癌症干细胞的潜力。

Potential to Eradicate Cancer Stemness by Targeting Cell Surface GRP78.

机构信息

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Kweishan, Taoyuan 33305, Taiwan.

Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.

出版信息

Biomolecules. 2022 Jul 5;12(7):941. doi: 10.3390/biom12070941.

DOI:10.3390/biom12070941

PMID:35883497

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9313351/

Abstract

Cancer stemness is proposed to be the main cause of metastasis and tumor relapse after conventional therapy due to the main properties of cancer stem cells. These include unlimited self-renewal, the low percentage in a cell population, asymmetric/symmetric cell division, and the hypothetical different nature for absorbing external substances. As the mechanism of how cancer stemness is maintained remains unknown, further investigation into the basic features of cancer stemness is required. Many articles demonstrated that glucose-regulated protein 78 (GRP78) plays a key role in cancer stemness, suggesting that this molecule is feasible for targeting cancer stem cells. This review summarizes the history of finding cancer stem cells, as well as the functions of GRP78 in cancer stemness, for discussing the possibility of targeting GRP78 to eradicate cancer stemness.

摘要

癌症干细胞干性被认为是常规治疗后转移和肿瘤复发的主要原因，这是由于癌症干细胞的主要特性所致。这些特性包括无限自我更新、细胞群体中低比例、不对称/对称细胞分裂以及吸收外部物质的假设不同性质。由于癌症干细胞干性维持的机制尚不清楚，因此需要进一步研究癌症干细胞干性的基本特征。许多文章表明，葡萄糖调节蛋白 78（GRP78）在癌症干细胞干性中发挥关键作用，这表明该分子可用于针对癌症干细胞。本综述总结了寻找癌症干细胞的历史，以及 GRP78 在癌症干细胞干性中的作用，以探讨针对 GRP78 以根除癌症干细胞干性的可能性。