经颅直流电刺激促进任务特异性运动学习的神经机制。
Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation.
机构信息
Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
Neurosci Bull. 2023 Jan;39(1):69-82. doi: 10.1007/s12264-022-00901-1. Epub 2022 Jul 30.
The optimal protocol for neuromodulation by transcranial direct current stimulation (tDCS) remains unclear. Using the rotarod paradigm, we found that mouse motor learning was enhanced by anodal tDCS (3.2 mA/cm) during but not before or after the performance of a task. Dual-task experiments showed that motor learning enhancement was specific to the task accompanied by anodal tDCS. Studies using a mouse model of stroke induced by middle cerebral artery occlusion showed that concurrent anodal tDCS restored motor learning capability in a task-specific manner. Transcranial in vivo Ca imaging further showed that anodal tDCS elevated and cathodal tDCS suppressed neuronal activity in the primary motor cortex (M1). Anodal tDCS specifically promoted the activity of task-related M1 neurons during task performance, suggesting that elevated Hebbian synaptic potentiation in task-activated circuits accounts for the motor learning enhancement. Thus, application of tDCS concurrent with the targeted behavioral dysfunction could be an effective approach to treating brain disorders.
经颅直流电刺激（tDCS）的最佳方案仍不明确。我们通过转棒实验发现，在任务执行过程中而非执行前后给予阳极 tDCS（3.2 mA/cm）可增强小鼠的运动学习能力。双重任务实验表明，运动学习增强是与阳极 tDCS 伴随的任务特异性的。使用大脑中动脉闭塞诱导的中风小鼠模型的研究表明，同时给予阳极 tDCS 可特异性地恢复特定任务的运动学习能力。经颅活体 Ca 成像进一步表明，阳极 tDCS 可升高而阴极 tDCS 可抑制初级运动皮层（M1）中的神经元活动。阳极 tDCS 可在任务执行过程中特异性促进与任务相关的 M1 神经元的活动，这表明任务激活回路中增强的赫布突触增强可解释运动学习的增强。因此，在靶向行为障碍的同时应用 tDCS 可能是治疗脑部疾病的有效方法。
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