Department of Pediatrics, University of California Davis Health, University of California Davis School of Medicine, CA.
Division of Emergency Medicine, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine in St. Louis, St Louis, MO.
J Pediatr. 2022 Nov;250:100-104. doi: 10.1016/j.jpeds.2022.07.033. Epub 2022 Aug 6.
Previous studies have identified more severe acidosis and higher blood urea nitrogen (BUN) as risk factors for cerebral injury during treatment of diabetic ketoacidosis (DKA) in children; however, cerebral injury also can occur before DKA treatment. We found that lower pH and higher BUN levels also were associated with cerebral injury at presentation.
先前的研究已经确定,酸中毒更严重和血尿素氮(BUN)更高是儿童治疗糖尿病酮症酸中毒(DKA)期间发生脑损伤的危险因素;然而,脑损伤也可能在 DKA 治疗之前发生。我们发现,较低的 pH 值和更高的 BUN 水平也与就诊时的脑损伤有关。