治疗药物监测在持续性中枢神经系统感染治疗中的作用：一例病例报告及文献综述
Role of Therapeutic Drug Monitoring in the Treatment of Persistent Central Nervous System Infection: A Case Report and Review of the Literature.
作者信息
Wu En-Ling, Al-Heeti Omar, Hoff Brian M, Williams Janna L, Krueger Karen M, Santoiemma Phillip P, Rhodes Nathaniel J
机构信息
Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Department of Pharmacy, Loyola University Medical Center, Maywood, Illinois, USA.
出版信息
Open Forum Infect Dis. 2022 Jul 30;9(8):ofac392. doi: 10.1093/ofid/ofac392. eCollection 2022 Aug.
A patient presenting with recurrent ventriculoperitoneal shunt infection was found to have growing from cerebrospinal fluid (CSF), which remained persistently positive. Therapeutic monitoring of clarithromycin, imipenem, and linezolid in CSF and plasma revealed lower than expected concentrations, prompting alternative therapy and culture clearance on hospital day 42.
一名出现复发性脑室腹腔分流感染的患者，其脑脊液（CSF）培养发现有细菌生长，且该培养结果持续呈阳性。对脑脊液和血浆中的克拉霉素、亚胺培南和利奈唑胺进行治疗监测发现，其浓度低于预期，因此在住院第42天更换了治疗方案并清除了培养物中的细菌。
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