癌症转移与钙信号作为潜在治疗靶点的研究进展。
Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets.
作者信息
Cui Chaochu, Zhang Yongxi, Liu Gang, Zhang Shuhong, Zhang Jinghang, Wang Xianwei
机构信息
Henan Key Laboratory of Medical Tissue Regeneration, College of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, Henan, China.
Department of Oncology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453003, Henan, China.
出版信息
Explor Target Antitumor Ther. 2021;2(3):266-291. doi: 10.37349/etat.2021.00046. Epub 2021 Jun 28.
Metastasis is still the primary cause of cancer-related mortality. However, the underlying mechanisms of cancer metastasis are not yet fully understood. Currently, the epithelial-mesenchymal transition, metabolic remodeling, cancer cell intercommunication and the tumor microenvironment including diverse stromal cells, are reported to affect the metastatic process of cancer cells. Calcium ions (Ca) are ubiquitous second messengers that manipulate cancer metastasis by affecting signaling pathways. Diverse transporter/pump/channel-mediated Ca currents form Ca oscillations that can be decoded by Ca-binding proteins, which are promising prognostic biomarkers and therapeutic targets of cancer metastasis. This paper presents a review of the advances in research on the mechanisms underlying cancer metastasis and the roles of Ca-related signals in these events.
转移仍然是癌症相关死亡的主要原因。然而，癌症转移的潜在机制尚未完全明确。目前，据报道上皮-间质转化、代谢重塑、癌细胞间通讯以及包括多种基质细胞在内的肿瘤微环境会影响癌细胞的转移过程。钙离子（Ca）是普遍存在的第二信使，通过影响信号通路来调控癌症转移。多种转运体/泵/通道介导的Ca电流形成Ca振荡，这些振荡可被Ca结合蛋白解读，而Ca结合蛋白是很有前景的癌症转移预后生物标志物和治疗靶点。本文综述了癌症转移潜在机制以及Ca相关信号在这些过程中的作用的研究进展。
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