衰老会降低肺部的黏液纤毛清除功能。
Aging Diminishes Mucociliary Clearance of the Lung.
作者信息
Bailey Kristina L
机构信息
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USA.
Research Service, VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105, USA.
出版信息
Adv Geriatr Med Res. 2022;4(2). doi: 10.20900/agmr20220005. Epub 2022 Jun 27.
Healthy aging leads to a decrease in mucociliary clearance of the lung. Mucociliary clearance is an essential innate immune defense to protect against inhaled particles and microbes. Mucociliary clearance can be affected by changes in cilia function as well as mucus quantity and qualities. With aging, cilia beat frequency slows and there are changes to the characteristics of mucus. These decreases in mucociliary clearance may lead to lung infection such as pneumonia or airway diseases such as bronchiectasis or Chronic Obstructive Pulmonary Diseases.
健康衰老会导致肺部黏液纤毛清除功能下降。黏液纤毛清除是一种重要的先天性免疫防御机制，可抵御吸入的颗粒和微生物。黏液纤毛清除功能会受到纤毛功能以及黏液数量和质量变化的影响。随着年龄增长，纤毛摆动频率减慢，黏液特性也会发生变化。黏液纤毛清除功能的这些下降可能导致肺部感染，如肺炎，或气道疾病，如支气管扩张或慢性阻塞性肺疾病。
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