安全靶向广泛表达的可溶性腺苷酸环化酶用于避孕的策略。
Strategies to safely target widely expressed soluble adenylyl cyclase for contraception.
作者信息
Ferreira Jacob, Levin Lonny R, Buck Jochen
机构信息
Department of Pharmacology, Weill Cornell Medicine, New York, NY, United States.
出版信息
Front Pharmacol. 2022 Aug 25;13:953903. doi: 10.3389/fphar.2022.953903. eCollection 2022.
In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate regulated soluble adenylyl cyclase (sAC; ADCY10). This review details why sAC is uniquely druggable and outlines ways to target sAC for novel forms of male and female contraception.
在人类中，典型的第二信使环磷酸腺苷（cAMP）由10种腺苷酸环化酶同工型产生，这些同工型分为两类。9种同工型是G蛋白偶联跨膜腺苷酸环化酶（tmACs；ADCY1-9），第10种是碳酸氢盐调节的可溶性腺苷酸环化酶（sAC；ADCY10）。本综述详细阐述了为什么sAC具有独特的可药用性，并概述了针对sAC开发新型男女避孕方法的途径。
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