BCAT1 通过增强线粒体功能和 NF-κB 通路激活促进肺腺癌进展。
BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation.
机构信息
Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China.
School of Basic Medical Sciences, Academy of Medical Science, Zhengzhou University, Zhengzhou 450052, China.
出版信息
J Zhejiang Univ Sci B. 2022;23(9):760-769. doi: 10.1631/jzus.B2100985.
Abstract
Lung cancer is one of the most prevalent and malignant cancers, among which lung adenocarcinoma (LUAD) accounts for the majority and remains a major cause of cancer-related mortality worldwide (Cui et al., 2019). Despite the growing intensity of research on the pathobiology and progression of lung cancer and the fact that many genes have been identified as potential drivers and targets for therapy (Luo et al., 2019; Zhang et al., 2019), the treatment and prognosis of lung cancer patients have hardly improved. Therefore, this study aimed to investigate the precise mechanism of lung cancer development and explore efficient diagnostic and therapeutic methods for clinical treatment.
摘要
肺癌是最常见和恶性的癌症之一，其中肺腺癌（LUAD）占大多数，仍然是全球癌症相关死亡的主要原因（Cui 等人，2019 年）。尽管对肺癌的病理生物学和进展进行了越来越多的研究，并且已经确定了许多基因作为潜在的治疗驱动因素和靶点（Luo 等人，2019 年；Zhang 等人，2019 年），但肺癌患者的治疗和预后几乎没有改善。因此，本研究旨在探讨肺癌发生的精确机制，并探索有效的诊断和治疗方法用于临床治疗。
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