感染人类免疫缺陷病毒者中心力衰竭及其他心血管疾病的全国趋势

National trend of heart failure and other cardiovascular diseases in people living with human immunodeficiency virus.

作者信息

Park Dae Yong, An Seokyung, Romero Maria Emilia, Murthi Mukunthan, Atluri Ramtej

机构信息

Department of Medicine, Cook County Health, Chicago, IL 60612, United States.

Department of Biomedical Science, Seoul National University Graduate School, Seoul 03080, South Korea.

出版信息

World J Cardiol. 2022 Jul 26;14(7):427-437. doi: 10.4330/wjc.v14.i7.427.

DOI:10.4330/wjc.v14.i7.427

PMID:36161061

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9350607/

Abstract

BACKGROUND

As people living with human immunodeficiency virus (HIV) (PLWH) enjoy longer life expectancy with highly effective antiretroviral therapy, they are encountering challenging cardiovascular health risks.

AIM

To retrospectively examine the increasing burden of cardiovascular diseases in PLWH over the past decade.

METHODS

All hospitalizations for heart failure (HF), ischemic heart disease (IHD), and cerebrovascular disease (CeVD) in PLWH were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) and ICD-10-CM codes in the National Inpatient Sample from 2008 to 2018. Outcomes included number of hospitalizations, in-hospital mortality, length of stay, and total hospital charge. Trend of the outcomes from 2008 to 2018 were analyzed using Cochran-Armitage trend test and simple linear regression.

RESULTS

The number of hospitalizations for HF in PLWH increased from 4212 in 2008 to 6700 in 2018 ( < 0.01). Similar increasing trend was seen with those for IHD and CeVD over the decade ( < 0.01). A decreasing trend of in-hospital mortality was observed in all hospitalizations of PLWH ( < 0.01) and CeVD in PLWH ( < 0.01), but not in those for HF ( = 0.67) and IHD ( = 0.13). The trend of length of stay was decreasing in all hospitalizations of PLWH ( < 0.01), but increasing in those for HF in PLWH ( < 0.01). An increasing trend of total hospital charge was observed in hospitalizations for HF, IHD, and CeVD ( < 0.01).

CONCLUSION

The burden of cardiovascular diseases has significantly increased in hospitalizations of PLWH from 2008 to 2018. Continued efforts are needed to address the additional cardiovascular risks in this vulnerable population.

摘要

背景

随着接受高效抗逆转录病毒治疗的人类免疫缺陷病毒（HIV）感染者（PLWH）预期寿命延长，他们正面临具有挑战性的心血管健康风险。

目的

回顾性研究过去十年PLWH中心血管疾病负担的增加情况。

方法

使用国际疾病分类第九版临床修订本（ICD-9-CM）和第十版临床修订本（ICD-10-CM）编码，在2008年至2018年的全国住院患者样本中识别PLWH中所有因心力衰竭（HF）、缺血性心脏病（IHD）和脑血管疾病（CeVD）住院的病例。结局包括住院次数、住院死亡率、住院时间和总住院费用。使用 Cochr an-Armitage趋势检验和简单线性回归分析2008年至2018年结局的趋势。

结果

PLWH中HF的住院次数从2008年的4212次增加到2018年的6700次（<0.01）。在这十年中，IHD和CeVD的住院次数也呈现类似的增加趋势（<0.01）。在PLWH的所有住院病例（<0.01）和PLWH中CeVD的住院病例（<0.01）中观察到住院死亡率呈下降趋势，但HF（=0.67）和IHD（=0.13）的住院死亡率未呈现下降趋势。PLWH所有住院病例的住院时间呈下降趋势（<0.01），但PLWH中HF的住院时间呈上升趋势（<0.01）。HF、IHD和CeVD住院病例的总住院费用呈上升趋势（<0.01）。