PM 导致的脂肪组织功能障碍可引发代谢紊乱。
PM-induced adipose tissue dysfunction can trigger metabolic disturbances.
机构信息
Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milano, Italy.
Department of Nutritional Sciences, College of Human Sciences, Texas Tech University, Lubbock, TX, USA.
出版信息
Trends Endocrinol Metab. 2022 Nov;33(11):737-740. doi: 10.1016/j.tem.2022.08.005. Epub 2022 Sep 27.
Exposure to particulate matter ≤2.5 μm in diameter (PM) alters cardiometabolic homeostasis. The reduced oxidative capacity in brown adipocytes and the development of inflammation and insulin resistance in white adipose tissue (WAT) can account for the dysmetabolic setting on PM exposure. In this forum article, we discuss relevant evidence to highlight a causal connection between PM-induced adipose tissue dysfunction and cardiometabolic disturbances.
暴露于直径≤2.5μm 的颗粒物（PM）会改变心脏代谢稳态。棕色脂肪细胞氧化能力下降，白色脂肪组织（WAT）发生炎症和胰岛素抵抗，这可以解释 PM 暴露导致的代谢异常。在本论坛文章中，我们讨论了相关证据，以强调 PM 诱导的脂肪组织功能障碍与心脏代谢紊乱之间的因果关系。
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