寡转移性食管癌（OMEC）项目研究方案：一项关于寡转移性食管癌定义与治疗的多学科欧洲共识项目。
Study protocol for the OligoMetastatic Esophagogastric Cancer (OMEC) project: A multidisciplinary European consensus project on the definition and treatment for oligometastatic esophagogastric cancer.
作者信息
Kroese Tiuri E, van Rossum Peter S N, Nilsson Magnus, Lordick Florian, Smyth Elizabeth C, Rosati Riccardo, Nafteux Philippe, D'Ugo Domenico, Chaudry M Asif, Polkowkski Wojciech, Roviello Franco, Gockel Ines, Kolodziejczyk Piotr, Haustermans Karin, Guckenberger Matthias, Nordsmark Marianne, Hawkins Maria A, Cervantes Andres, Fleitas Tania, van Cutsem Eric, Moehler Markus, Wagner Anna D, van Laarhoven Hanneke W M, van Hillegersberg Richard
机构信息
Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
出版信息
Eur J Surg Oncol. 2023 Jan;49(1):21-28. doi: 10.1016/j.ejso.2022.09.012. Epub 2022 Sep 24.
BACKGROUND
A uniform definition and treatment for oligometastatic esophagogastric cancer is currently lacking. However, a comprehensive definition of oligometastatic esophagogastric cancer is necessary to initiate studies on local treatment strategies (e.g. metastasectomy or stereotactic radiotherapy) and new systemic therapy agents in this group of patients. For this purpose, the OligoMetastatic Esophagogastric Cancer (OMEC) project was established. The OMEC-project aims to develop a multidisciplinary European consensus statement on the definition, diagnosis, and treatment for oligometastatic esophagogastric cancer and provide a framework for prospective studies to improve outcomes of these patients.
METHODS
The OMEC-project consists of five studies, including 1) a systematic review on definitions and outcomes of oligometastatic esophagogastric cancer; 2) real-life clinical scenario discussions in multidisciplinary expert teams to determine the variation in the definition and treatment strategies; 3) Delphi consensus process through a starting meeting, two Delphi questionnaire rounds, and a consensus meeting; 4) publication of a multidisciplinary European consensus statement; and 5) a prospective clinical trial in patients with oligometastatic esophagogastric cancer.
DISCUSSION
The OMEC project aims to establish a multidisciplinary European consensus statement for oligometastatic esophagogastric cancer and aims to initiate a prospective clinical trial to improve outcomes for these patients. Recommendations from OMEC can be used to update the relevant guidelines on treatment for patients with (oligometastatic) esophagogastric cancer.
背景
目前，对于寡转移性食管癌和胃癌缺乏统一的定义及治疗方法。然而，对于寡转移性食管癌和胃癌而言，要启动针对该类患者的局部治疗策略（如转移灶切除术或立体定向放疗）及新型全身治疗药物的研究，就必须要有一个全面的定义。为此，成立了寡转移性食管癌和胃癌（OMEC）项目。OMEC项目旨在就寡转移性食管癌和胃癌的定义、诊断及治疗制定一份多学科的欧洲共识声明，并为前瞻性研究提供一个框架，以改善这些患者的治疗效果。
方法
OMEC项目由五项研究组成，包括：1）对寡转移性食管癌和胃癌的定义及治疗效果进行系统综述；2）多学科专家团队进行现实临床场景讨论，以确定定义和治疗策略的差异；3）通过一次启动会议、两轮德尔菲问卷调查及一次共识会议进行德尔菲共识程序；4）发表一份多学科的欧洲共识声明；5）针对寡转移性食管癌和胃癌患者开展一项前瞻性临床试验。
讨论
OMEC项目旨在为寡转移性食管癌和胃癌制定一份多学科的欧洲共识声明，并旨在启动一项前瞻性临床试验以改善这些患者的治疗效果。OMEC的建议可用于更新（寡转移性）食管癌和胃癌患者治疗的相关指南。
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