Protective effect of Boiss against sodium nitrite-induced hepatotoxicity in rats.

OBJECTIVE

Sodium nitrite (NaNO) is used as a color stabilizer and antimicrobial agent in preservation of cured meat and fish. However, extensive use of this agent in the meat industries increased worries about its detrimental effects on human health. ( is a well-known plant with therapeutic properties in the traditional medicine Therefore, the present study was conducted to investigate the protective effect of this plant against sodium nitrite-induced hepatotoxicity.

MATERIALS AND METHODS

Thirty-two male Wistar rats were divided into 4 groups: Control (without any treatment), nitrite (350 mg/kg by gavage for 60 days), NaNO plus (rats treated with NaNO 350 mg/kg gavage for 60 days and simultaneously received extract at 200 mg/kg, ip) and group (rats treated with extract at 200 mg/kg, ip). At the end of the study, rats were euthanized and liver tissue samples were taken and studied under microscopy. Also, serum levels of liver function enzymes and antioxidant defense systems were measured. The results were analyzed using SPSS software and a p<0.0.5 was considered significant.

RESULTS

Results showed that NaNO induces liver injuries and altered hepatic histo-architecture. Also, NaNO significantly altered the biochemical profiles and antioxidant defense parameters of the liver. However, treatment with improved tissue integrity as well as antioxidant defense status and biochemical conditions of the liver.

CONCLUSION

Administration of extract has beneficial effects on the NaNO-induced histological and functional toxicity in the liver.