靶向肥胖的纳米技术和营养疗法：一种更新的方法。
Targeting Nanotechnology and Nutraceuticals in Obesity: An Updated Approach.
机构信息
Department of Pharmaceutics, MM College of Pharmacy, Maharishi Markandeshwar (Deemed to Be University), Mullana- Ambala, Haryana 133207, India.
School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India.
出版信息
Curr Pharm Des. 2022;28(40):3269-3288. doi: 10.2174/1381612828666221003105619.
HYPOTHESIS
This review article represents a brief layout of the risk factors and pathophysiology responsible for obesity, customary treatment strategies, and nanotechnology-based nutraceutical for the therapeutics of obesity.
EXPERIMENTS
An exhaustive search of the literature was done for this purpose, using Google Scholar, PubMed, and ScienceDirect databases. A literature study was conducted using publications published in peer-reviewed journals between 2000 and 2022.
FINDINGS
This was revealed that risk factors responsible for obesity were genetic abnormalities and environmental and socio-economic factors. Several research articles published between 2000 and 2022 were based on phytoconstituents-based nanoformulation for obesity therapeutics and, therefore, have been systematically compiled in this review. Various nutraceuticals like possessing anti-obesity actions are discussed in this review along with their patents, clinical trials as well as their nanoformulation available.
CONCLUSION
This review illustrates that nanotechnology has a great propensity to impart a promising role in delivering phytochemicals and nutraceuticals in managing obesity conditions and other related disorders.
假设
本文综述了导致肥胖的风险因素和病理生理学、常规治疗策略以及基于纳米技术的营养保健品在肥胖治疗中的应用。
实验
为此目的，使用 Google Scholar、PubMed 和 ScienceDirect 数据库进行了全面的文献检索。使用 2000 年至 2022 年期间在同行评审期刊上发表的出版物进行了文献研究。
结果
研究表明，导致肥胖的风险因素包括遗传异常以及环境和社会经济因素。本综述系统地汇编了 2000 年至 2022 年期间发表的基于植物成分的纳米制剂治疗肥胖症的多项研究文章。本文还讨论了具有抗肥胖作用的各种营养保健品及其专利、临床试验以及已有的纳米制剂。
结论
本文综述表明，纳米技术在提供植物化学物质和营养保健品以治疗肥胖症和其他相关疾病方面具有很大的潜力。
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