用于纳米技术和生物医药应用的重组蛋白聚合物-抗体缀合物。
Recombinant protein polymer-antibody conjugates for applications in nanotechnology and biomedicine.
机构信息
Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, United States.
Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, United States.
出版信息
Adv Drug Deliv Rev. 2022 Dec;191:114570. doi: 10.1016/j.addr.2022.114570. Epub 2022 Oct 10.
Currently, there are over 100 antibody-based therapeutics on the market for the treatment of various diseases. The increasing importance of antibody treatment is further highlighted by the recent FDA emergency use authorization of certain antibody therapies for COVID-19 treatment. Protein-based materials have gained momentum for antibody delivery due to their biocompatibility, tunable chemistry, monodispersity, and straightforward synthesis and purification. In this review, we discuss progress in engineering the molecular features of protein-based biomaterials, in particular recombinant protein polymers, for introducing novel functionalities and enhancing the delivery properties of antibodies and related binding protein domains.
目前，市场上有超过 100 种基于抗体的治疗药物可用于治疗各种疾病。最近，FDA 紧急批准了某些抗体疗法用于 COVID-19 的治疗，这进一步凸显了抗体治疗的重要性。由于蛋白质材料具有生物相容性、可调节的化学性质、单分散性以及简单的合成和纯化等特点，因此在抗体递送上得到了广泛的关注。在这篇综述中，我们讨论了在工程化蛋白质基生物材料（特别是重组蛋白聚合物）的分子特性方面的进展，这些进展旨在引入新的功能并增强抗体和相关结合蛋白结构域的递药性能。
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