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达巴万星作为慢性抗生素抑制疗法治疗耐甲氧西林金黄色葡萄球菌导致的左心室辅助装置移植物感染:一例报告。

Dalbavancin as chronic antibiotic suppression therapy for left ventricular assist device driveline infection due to methicillin-resistant : a case report.

机构信息

Infectious Diseases Clinic, Santa Maria della Misericordia Hospital, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Department of Cardiac Surgery, Santa Maria della Misericordia Hospital, Perugia, Italy.

出版信息

J Chemother. 2023 Sep;35(5):465-469. doi: 10.1080/1120009X.2022.2136426. Epub 2022 Oct 25.

Abstract

Left Ventricular Assist Devices (LVADs) represent an important therapeutic option in the management of advanced heart failure. We report a case of 74 years-old male with a Jarvik 2000® (Jarvik Heart, New York, USA) LVAD who presented with an infection of the LVAD driveline due to methicillin-resistant (MRSA) that was treated with dalbavancin as chronic antimicrobial suppression therapy without adverse events and maintaining a good quality of life for more than 37 weeks. Dalbavancin could represent a valid option for the treatment of LVAD infections because of its efficacy, pharmacokinetic/pharmacodynamic proprieties, safety and tolerability.

摘要

左心室辅助装置(LVAD)在治疗晚期心力衰竭方面是一种重要的治疗选择。我们报告了一例 74 岁男性患者,使用 Jarvik 2000®(Jarvik Heart,纽约,美国)LVAD,因耐甲氧西林金黄色葡萄球菌(MRSA)导致 LVAD 驱动轴感染,采用达巴万星进行慢性抗菌抑制治疗,无不良反应,生活质量良好超过 37 周。达巴万星由于其疗效、药代动力学/药效学特性、安全性和耐受性,可能是治疗 LVAD 感染的有效选择。

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