Infectious Diseases Clinic, Santa Maria della Misericordia Hospital, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Department of Cardiac Surgery, Santa Maria della Misericordia Hospital, Perugia, Italy.
J Chemother. 2023 Sep;35(5):465-469. doi: 10.1080/1120009X.2022.2136426. Epub 2022 Oct 25.
Left Ventricular Assist Devices (LVADs) represent an important therapeutic option in the management of advanced heart failure. We report a case of 74 years-old male with a Jarvik 2000® (Jarvik Heart, New York, USA) LVAD who presented with an infection of the LVAD driveline due to methicillin-resistant (MRSA) that was treated with dalbavancin as chronic antimicrobial suppression therapy without adverse events and maintaining a good quality of life for more than 37 weeks. Dalbavancin could represent a valid option for the treatment of LVAD infections because of its efficacy, pharmacokinetic/pharmacodynamic proprieties, safety and tolerability.
左心室辅助装置(LVAD)在治疗晚期心力衰竭方面是一种重要的治疗选择。我们报告了一例 74 岁男性患者,使用 Jarvik 2000®(Jarvik Heart,纽约,美国)LVAD,因耐甲氧西林金黄色葡萄球菌(MRSA)导致 LVAD 驱动轴感染,采用达巴万星进行慢性抗菌抑制治疗,无不良反应,生活质量良好超过 37 周。达巴万星由于其疗效、药代动力学/药效学特性、安全性和耐受性,可能是治疗 LVAD 感染的有效选择。