蛋白质数据库：研究人员、教育工作者和学生对 3D 结构库的综合评价及全球利用情况。
Protein Data Bank: A Comprehensive Review of 3D Structure Holdings and Worldwide Utilization by Researchers, Educators, and Students.
机构信息
Research Collaboratory for Structural Bioinformatics Protein Data Bank, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
出版信息
Biomolecules. 2022 Oct 4;12(10):1425. doi: 10.3390/biom12101425.
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), funded by the United States National Science Foundation, National Institutes of Health, and Department of Energy, supports structural biologists and Protein Data Bank (PDB) data users around the world. The RCSB PDB, a founding member of the Worldwide Protein Data Bank (wwPDB) partnership, serves as the US data center for the global PDB archive housing experimentally-determined three-dimensional (3D) structure data for biological macromolecules. As the wwPDB-designated Archive Keeper, RCSB PDB is also responsible for the security of PDB data and weekly update of the archive. RCSB PDB serves tens of thousands of data depositors (using macromolecular crystallography, nuclear magnetic resonance spectroscopy, electron microscopy, and micro-electron diffraction) annually working on all permanently inhabited continents. RCSB PDB makes PDB data available from its research-focused web portal at no charge and without usage restrictions to many millions of PDB data consumers around the globe. It also provides educators, students, and the general public with an introduction to the PDB and related training materials through its outreach and education-focused web portal. This review article describes growth of the PDB, examines evolution of experimental methods for structure determination viewed through the lens of the PDB archive, and provides a detailed accounting of PDB archival holdings and their utilization by researchers, educators, and students worldwide.
美国国家科学基金会、美国国立卫生研究院和美国能源部共同资助的结构生物信息学研究协作组织——蛋白质数据库（RCSB PDB），为全世界的结构生物学家和蛋白数据库（PDB）数据使用者提供支持。RCSB PDB 作为全球蛋白数据库（wwPDB）合作组织的创始成员之一，作为包含生物大分子实验测定的三维（3D）结构数据的全球 PDB 档案库的美国数据中心而存在。作为 wwPDB 指定的档案库管理员，RCSB PDB 还负责 PDB 数据的安全以及每周对档案库的更新。RCSB PDB 每年为分布在全球各地的、来自于数千名数据提供者（使用大分子晶体学、核磁共振光谱学、电子显微镜和微电子衍射技术）的研究提供服务。RCSB PDB 通过其以研究为重点的门户网站免费提供 PDB 数据，并且对全球数以百万计的 PDB 数据使用者没有使用限制。RCSB PDB 还通过其外联和教育为重点的门户网站，为教育工作者、学生和公众提供了 PDB 及相关培训材料的介绍。本文综述了 PDB 的发展历程，通过 PDB 档案库的视角，考察了结构测定实验方法的演变，并详细介绍了 PDB 的档案库持有情况及其在全世界范围内被研究人员、教育工作者和学生的利用情况。
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