可增强线粒体自噬以延缓衰老和神经退行性变的小分子。 - Suppr

Small molecules that enhance mitophagy to delay aging and neurodegeneration.

作者信息

Dorn Gerald W

机构信息

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

出版信息

J Cardiovasc Aging. 2022 Oct;2(4). doi: 10.20517/jca.2022.36. Epub 2022 Sep 13.

DOI:10.20517/jca.2022.36

PMID:36340925

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9624469/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1159/9624469/ed025b153819/nihms-1835903-f0001.jpg

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Front Cell Dev Biol. 2020 Apr 15;8:239. doi: 10.3389/fcell.2020.00239. eCollection 2020.

Evolving and Expanding the Roles of Mitophagy as a Homeostatic and Pathogenic Process.

Physiol Rev. 2019 Jan 1;99(1):853-892. doi: 10.1152/physrev.00005.2018.

Evolving Concepts of Mitochondrial Dynamics.

Annu Rev Physiol. 2019 Feb 10;81:1-17. doi: 10.1146/annurev-physiol-020518-114358. Epub 2018 Sep 26.

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本文引用的文献

Distinct designer diamines promote mitophagy, and thereby enhance healthspan in and protect human cells against oxidative damage.

Autophagy. 2023 Feb;19(2):474-504. doi: 10.1080/15548627.2022.2078069. Epub 2022 Jun 1.

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Front Physiol. 2020 Jul 9;11:782. doi: 10.3389/fphys.2020.00782. eCollection 2020.

MitophAging: Mitophagy in Aging and Disease.

Front Cell Dev Biol. 2020 Apr 15;8:239. doi: 10.3389/fcell.2020.00239. eCollection 2020.

Evolving and Expanding the Roles of Mitophagy as a Homeostatic and Pathogenic Process.

Physiol Rev. 2019 Jan 1;99(1):853-892. doi: 10.1152/physrev.00005.2018.

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Annu Rev Physiol. 2019 Feb 10;81:1-17. doi: 10.1146/annurev-physiol-020518-114358. Epub 2018 Sep 26.

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J Clin Invest. 2018 Aug 31;128(9):3662-3670. doi: 10.1172/JCI120842. Epub 2018 Jul 30.

Spermidine in health and disease.

Science. 2018 Jan 26;359(6374). doi: 10.1126/science.aan2788.

How mitochondrial dynamism orchestrates mitophagy.

Circ Res. 2015 May 22;116(11):1835-49. doi: 10.1161/CIRCRESAHA.116.306374.

Mechanisms of mitophagy.

Nat Rev Mol Cell Biol. 2011 Jan;12(1):9-14. doi: 10.1038/nrm3028.

Mitochondrial fragmentation in neurodegeneration.

Nat Rev Neurosci. 2008 Jul;9(7):505-18. doi: 10.1038/nrn2417.

Small molecules that enhance mitophagy to delay aging and neurodegeneration.

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