AO Research Institute Davos, Davos Platz, Switzerland.
UCB Pharma, Slough, UK.
Methods Mol Biol. 2023;2598:1-7. doi: 10.1007/978-1-0716-2839-3_1.
Once damaged, cartilage has limited healing capability. This has led to a huge body of research that aims to repair or regenerate this important tissue. Despite the progress made, significant hurdles still need to be overcome. This chapter highlights some of the progress made, while elaborating on areas that need further research. The concept of translation and the route to clinical translation must be kept in mind if some of the promising preclinical research is to make it to routine clinical application.
一旦软骨受损,其自我修复能力十分有限。这导致了大量旨在修复或再生这种重要组织的研究。尽管已经取得了一些进展,但仍有许多重大障碍需要克服。本章重点介绍了一些已取得的进展,同时阐述了需要进一步研究的领域。如果一些有前景的临床前研究想要转化为常规的临床应用,就必须牢记翻译的概念和临床转化途径。