黑色素瘤的靶向治疗和免疫治疗。

Targeted Therapy and Immunotherapy in Melanoma.

机构信息

Department of Medicine, Section of Dermatology, University of Chicago, The University of Chicago Medicine, 5841 S Maryland Avenue MC 5067, Chicago, IL 60637, USA.

出版信息

Dermatol Clin. 2023 Jan;41(1):65-77. doi: 10.1016/j.det.2022.07.007. Epub 2022 Oct 28.

DOI:10.1016/j.det.2022.07.007

PMID:36410984

Abstract

While metastatic melanoma still carries significant mortality rates, the introduction of targeted therapy with BRAF/MEK inhibition and immunotherapy with PD-1, PD-L1, and CTLA-4 inhibitors has led to significant strides in outcomes and prognosis.

摘要

虽然转移性黑色素瘤仍然具有显著的死亡率，但 BRAF/MEK 抑制的靶向治疗和 PD-1、PD-L1 和 CTLA-4 抑制剂的免疫治疗的引入，已经使得在治疗结果和预后方面取得了重大进展。