基于谷胱甘肽-抗坏血酸功能化的氧化钼量子点的荧光传感器用于检测药物样品中的异烟肼药物。
Glutathione-ascorbic acid-functionalized molybdenum oxide quantum dots-based fluorescent sensor for the detection of isoniazid drug in pharmaceutical samples.
机构信息
Department of Chemistry, Sardar Vallbhbhai National Institute of Technology, Surat 395 007, Gujarat, India.
Department of Chemistry, Sardar Vallbhbhai National Institute of Technology, Surat 395 007, Gujarat, India.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2023 Feb 15;287(Pt 1):122041. doi: 10.1016/j.saa.2022.122041. Epub 2022 Oct 25.
Herein, glutathione-ascorbic acid-functionalized molybdenum oxide quantum dots (GSH-AA-MoO QDs) are synthesized by the conventional method and used as a fluorescent probe for the rapid detection of isoniazid drug in pharmaceutical samples. Ascorbic acid and glutathione are used as surface ligands for the modification of MoO QDs. The as-synthesized GSH-AA-MoO QDs display λ at 416 nm when applied λ at 330 nm. The introduction of isoniazid drug into GSH-AA-MoO QDs solution results the assembly of GSH-AA-MoO QDs-isoniazid nanoarchitectures, leading to quench λ at 416 nm. Thus, GSH-AA-MoO QDs can work as a fluorescent sensor for the rapid identification of isoniazid in real samples. The as-prepared GSH-AA-MoO QDs not only allows superior analytical features (rapidity, and selectivity) toward isoniazid with the detection limit of 94 nM, but also displays fluorescence "turn-off" response for assaying of isoniazid in real samples (pharmaceutical and biofluids). Finally, GSH-AA-MoO QDs are highly promising fluorescent probe for the rapid detection of isoniazid in real samples.
本文通过常规方法合成了谷胱甘肽-抗坏血酸功能化的氧化钼量子点（GSH-AA-MoO QDs），并将其用作药物样品中异烟肼药物快速检测的荧光探针。抗坏血酸和谷胱甘肽用作 MoO QDs 表面配体的修饰。合成的 GSH-AA-MoO QDs 在应用 330nm 时显示出 416nm 的 λ。异烟肼药物的引入导致 GSH-AA-MoO QDs 溶液中 GSH-AA-MoO QDs-异烟肼纳米结构的组装，导致 416nm 的 λ 猝灭。因此，GSH-AA-MoO QDs 可以作为一种荧光传感器，用于快速识别实际样品中的异烟肼。所制备的 GSH-AA-MoO QDs 不仅对异烟肼具有优越的分析特性（快速性和选择性），检测限低至 94nM，而且还对实际样品（药物和生物流体）中的异烟肼进行荧光“关闭”响应分析。最后，GSH-AA-MoO QDs 是一种很有前途的用于快速检测实际样品中异烟肼的荧光探针。
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