基于铜促进吡啶甲酸部分水解反应的荧光开关探针的研究进展。
Development in Fluorescent OFF-ON Probes Based on Cu Promoted Hydrolysis Reaction of the Picolinate Moiety.
作者信息
Ahmed Nadeem, Zareen Wajeeha, Yang Xiaopeng, Shafiq Zahid, Ye Yong
机构信息
Phosphorus Chemical Engineering Research Center of Henan Province, College of Chemistry, Zhengzhou University, Zhengzhou, 450002, China.
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
出版信息
J Fluoresc. 2023 Mar;33(2):401-411. doi: 10.1007/s10895-022-03078-y. Epub 2022 Dec 8.
Anions and cations have a key role in our normal life. Cu ion is a crucial trace element accountable for the part of several cellular enzymes and proteins, including cytochrome c oxidase, dopamine monooxygenase, Cu/Zn superoxide dismutase, and ceruloplasmin. WHO has found the extreme acceptable level of Cu ions in drinking water is up to 2.0 ppm. Excess use of Cu ions is associated with various human genetic disorders. Thus, the visualization of Cu ions to avoid its toxic effects in chemical and biological systems is significant. In this review we have summarized sensors based on catalytic hydrolysis of picolinate to detect Cu ions. The sensors based on hydrolysis of picolinate are very selective as compared to the other sensors for Cu ions detection. We have focused on describing the structure, spectral properties, detection limits, and bioimaging model of the sensors.
阴离子和阳离子在我们的正常生活中起着关键作用。铜离子是一种至关重要的微量元素，它在多种细胞酶和蛋白质中发挥作用，包括细胞色素c氧化酶、多巴胺单加氧酶、铜/锌超氧化物歧化酶和铜蓝蛋白。世界卫生组织发现饮用水中铜离子的最大可接受水平高达2.0 ppm。过量使用铜离子与各种人类遗传疾病有关。因此，在化学和生物系统中可视化铜离子以避免其毒性作用具有重要意义。在这篇综述中，我们总结了基于吡啶甲酸催化水解来检测铜离子的传感器。与其他用于检测铜离子的传感器相比，基于吡啶甲酸水解的传感器具有很高的选择性。我们重点描述了这些传感器的结构、光谱特性、检测限和生物成像模型。
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