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实体器官移植术后慢性术后疼痛和持续阿片类药物使用的预防和管理:多伦多综合医院过渡性疼痛服务的经验。

Prevention and Management of Chronic Postsurgical Pain and Persistent Opioid Use Following Solid Organ Transplantation: Experiences From the Toronto General Hospital Transitional Pain Service.

机构信息

Department of Anesthesia and Pain Management, Toronto General Hospital, Toronto, ON, Canada.

Transitional Pain Service, Department of Anesthesia and Pain Management, Toronto General Hospital, Toronto, ON, Canada.

出版信息

Transplantation. 2023 Jun 1;107(6):1398-1405. doi: 10.1097/TP.0000000000004441. Epub 2022 Dec 9.

Abstract

BACKGROUND

With >700 transplant surgeries performed each year, Toronto General Hospital (TGH) is currently one of the largest adult transplant centers in North America. There is a lack of literature regarding both the identification and management of chronic postsurgical pain (CPSP) after organ transplantation. Since 2014, the TGH Transitional Pain Service (TPS) has helped manage patients who developed CPSP after solid organ transplantation (SOT), including heart, lung, liver, and renal transplants.

METHODS

In this retrospective cohort study, we describe the association between opioid consumption, psychological characteristics of pain, and demographic characteristics of 140 SOT patients who participated in the multidisciplinary treatment at the TGH TPS, incorporating psychology and physiotherapy as key parts of our multimodal pain management regimen.

RESULTS

Treatment by the multidisciplinary TPS team was associated with significant improvement in pain severity and a reduction in opioid consumption.

CONCLUSIONS

Given the risk of CPSP after SOT, robust follow-up and management by a multidisciplinary team should be considered to prevent CPSP, help guide opioid weaning, and provide psychological support to these patients to improve their recovery trajectory and quality of life postoperatively.

摘要

背景

多伦多总医院(TGH)每年进行超过 700 例移植手术,目前是北美最大的成人移植中心之一。目前,关于器官移植后慢性手术后疼痛(CPSP)的识别和管理,相关文献还比较缺乏。自 2014 年以来,TGH 过渡性疼痛服务(TPS)一直在帮助管理发生 CPSP 的实体器官移植(SOT)患者,包括心脏、肺、肝和肾移植。

方法

在这项回顾性队列研究中,我们描述了接受 TGH TPS 多学科治疗的 140 名 SOT 患者的阿片类药物消耗、疼痛心理特征与人口统计学特征之间的关系,将心理学和物理疗法纳入我们的多模式疼痛管理方案的关键部分。

结果

多学科 TPS 团队的治疗与疼痛严重程度的显著改善和阿片类药物消耗的减少相关。

结论

鉴于 SOT 后发生 CPSP 的风险,应考虑由多学科团队进行强有力的随访和管理,以预防 CPSP,帮助指导阿片类药物的逐渐减少,并为这些患者提供心理支持,以改善他们术后的恢复轨迹和生活质量。

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