The ethanolic extract of the fungus decreases the replication and ameliorates the experimental toxoplasmosis .

are fungi that are well-known to inhibit the growth of a variety of plant pathogens. Currently, there is an increasing search for new drugs to treat toxoplasmosis. The aims of this study were to investigate the effect of Ext in the control of proliferation and the course of toxoplasmosis in a mouse model. Firstly, the cytotoxicity of the Ext was evaluated by cultivating macrophages with different concentrations of the extract and cell viability was assessed by the MTT assay. Next, the infectivity of the treated with extract was analyzed by infecting J774 macrophages. To evaluate the effect of the Ext, C57BL/6 mice were infected orally with ME-49, treated daily with Ext, and clinical, biochemical and histological changes were monitored. It was demonstrated that the extract did not affect the host cellular viability and, the treatment of parasites with Ext altered their morphology and decreased their ability to proliferate inside macrophages. Additionally, the treatment of mice with Ext decreased the parasitism and inflammation in the small intestine and liver of infected mice in parallel with increased IL-10/TNF ratio systemically and prevented alterations to serum VLDL and triglyceride levels. Thus, Ext could be considered an alternative/complementary therapy to control toxoplasmosis.