非编码RNA的N6-甲基腺苷修饰：机制及其在癌症中的临床应用
N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer.
作者信息
Ma Mingyang, Ye Tong, Wang Jiewei, Zhao Haiying, Zhang Shutian, Li Peng, Zhao Guiping
机构信息
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
出版信息
Diagnostics (Basel). 2022 Nov 30;12(12):2996. doi: 10.3390/diagnostics12122996.
N6-methyladenosine (m6A) modification remains the most pivotal epigenetic modification on RNA. As we know, m6A not only affects physiological processes but is also involved in carcinoma. Noncoding RNAs play an indispensable role in the occurrence and development of carcinoma. However, a large amount of research is focused on mRNA currently. Insufficient research has been done on the relationship between noncoding RNA (ncRNA) methylation and cancer. Therefore, this review aims to introduce the theoretical knowledge of m6A modification in noncoding RNA, discuss its function in tumorigenesis and progression, and ultimately summarize its potential clinical applications.
N6-甲基腺苷（m6A）修饰仍然是RNA上最关键的表观遗传修饰。众所周知，m6A不仅影响生理过程，还参与癌症发生。非编码RNA在癌症的发生和发展中发挥着不可或缺的作用。然而，目前大量研究集中在mRNA上。关于非编码RNA（ncRNA）甲基化与癌症之间的关系，研究尚不充分。因此，本综述旨在介绍非编码RNA中m6A修饰的理论知识，探讨其在肿瘤发生和进展中的作用，并最终总结其潜在的临床应用。
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