长期高强度灭火工作的炎症及心理影响

Inflammatory and psychological consequences of chronic high exposure firefighting.

作者信息

Richardson Alan, Terrazzini Nadia, Gage Catherine, Lee Ben James, Bradley Rebecca, Watt Peter, Watkins Emily Rachel

机构信息

Environmental Extremes Group, University of Brighton, UK; Centre for Stress, Aging and Disease, University of Brighton, UK.

Centre for Stress, Aging and Disease, University of Brighton, UK.

出版信息

J Therm Biol. 2023 Jan;111:103399. doi: 10.1016/j.jtherbio.2022.103399. Epub 2022 Nov 25.

DOI:10.1016/j.jtherbio.2022.103399

PMID:36585074

Abstract

OBJECTIVES

This study aimed to examine the impact of extreme heat exposure frequency on inflammation and well-being in UK Fire Service personnel.

METHODS

136 Fire personnel and 14 controls (CON) were recruited [92 Firefighters (FF), 44 Breathing Apparatus Instructors (BAI)]. BAI were split into low (LBAI; ≤15 exposures per month) and high (HBAI; ≥20 exposures per month) categories. Measures of inflammation, mood and fatigue were collected at 0, 3 and 6 month times points. These variables were analysed for differences between groups and association with frequency of exposure.

RESULTS

HBAI exhibited raised IL-1β, IL-6, IL-10, IgE and lower IgM (p < 0.05). In addition, IL-1β, IL-6, IL-10 and IgM were associated with monthly exposure number, with exposures accounting for 15.4% of the variance in IL-6, 11.8% of IL-1β and 25.2% of IL-10. No differences in mood or fatigue were reported (p > 0.05).

CONCLUSION

High exposure firefighting consistently causes systemic inflammation without perceptual recognition of potential health risks.

摘要

目的

本研究旨在探讨极端高温暴露频率对英国消防人员炎症和健康状况的影响。

方法

招募了136名消防人员和14名对照人员（CON）[92名消防员（FF），44名呼吸设备教员（BAI）]。BAI被分为低暴露组（LBAI；每月暴露≤15次）和高暴露组（HBAI；每月暴露≥20次）。在0、3和6个月时间点收集炎症、情绪和疲劳指标。分析这些变量在组间的差异以及与暴露频率的关联。

结果

HBAI组的白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、免疫球蛋白E（IgE）升高，免疫球蛋白M（IgM）降低（p<0.05）。此外，IL-1β、IL-6、IL-10和IgM与每月暴露次数相关，暴露次数分别解释了IL-6变异的15.4%、IL-1β变异的11.8%和IL-10变异的25.2%。情绪或疲劳方面未报告差异（p>0.05）。