原发性卵巢功能不全患者的自身免疫和免疫特征综述。
A review of autoimmunity and immune profiles in patients with primary ovarian insufficiency.
机构信息
Departments of Gynecology and Obstetrics, The Second Hospital of Jilin University, Changchun, China.
Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University, School of Medicine, Hangzhou, China.
出版信息
Medicine (Baltimore). 2022 Dec 23;101(51):e32500. doi: 10.1097/MD.0000000000032500.
Primary ovarian insufficiency (POI) is a complicated clinical syndrome characterized by progressive deterioration of ovarian function. Autoimmunity is one of the main pathogenic factors affecting approximately 10% to 55% of POI cases. This review mainly focuses on the role of autoimmunity in the pathophysiology of POI and the potential therapies for autoimmunity-related POI. This review concluded that various markers of ovarian reserve, principally anti-Müllerian hormone, could be negatively affected by autoimmune diseases. The presence of lymphocytic oophoritis, anti-ovarian autoantibodies, and concurrent autoimmune diseases, are the main characteristics of autoimmune POI. T lymphocytes play the most important role in the immune pathogenesis of POI, followed by disorders of other immune cells and the imbalance between pro-inflammatory and anti-inflammatory cytokines. A comprehensive understanding of immune characteristics of patients with autoimmune POI and the underlying mechanisms is essential for novel approaches of treatment and intervention for autoimmune POI.
原发性卵巢功能不全（POI）是一种以卵巢功能进行性恶化为特征的复杂临床综合征。自身免疫是影响约 10%至 55%的 POI 病例的主要致病因素之一。本综述主要关注自身免疫在 POI 病理生理学中的作用以及针对自身免疫相关 POI 的潜在治疗方法。本综述得出结论，各种卵巢储备标志物，主要是抗苗勒管激素，可能会受到自身免疫性疾病的负面影响。淋巴细胞性卵巢炎、抗卵巢自身抗体和同时存在的自身免疫性疾病是自身免疫性 POI 的主要特征。T 淋巴细胞在 POI 的免疫发病机制中起着最重要的作用，其次是其他免疫细胞的紊乱以及促炎和抗炎细胞因子之间的失衡。全面了解自身免疫性 POI 患者的免疫特征及其潜在机制，对于自身免疫性 POI 的新型治疗和干预方法至关重要。
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