实验室动物睾丸组织再生的干细胞治疗试验。
Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals.
机构信息
Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, 12211, Giza, Egypt.
Department of Cytology and Histology , Faculty of Veterinary Medicine, Cairo University, 12211, Giza, Egypt.
出版信息
Reprod Sci. 2023 Jun;30(6):1770-1781. doi: 10.1007/s43032-022-01152-1. Epub 2023 Jan 5.
Infertility is a serious medical, economic, and psychological problem in the society. Male factor infertility, due to defective spermatogenesis as a result of a failure in germ cell proliferation and differentiation, appears to be the cause of 25-50% of infertility cases. According to several surveys, testicular degeneration can be caused by a variety of physical, chemical, and microbial causes. A stem cell is a non-specialized cell which is characterized by self-renewal by mitotic cell division and able to differentiate to specialized cells for the various tissues of the body. The data were obtained and analyzed from different databases (PubMed, Google Scholar, Egyptian Knowledge Bank, Elsevier, Medline, Embase, ProQuest, and BMC). This review discusses the causes, symptoms, and grades of testicular degeneration and the use of different types of stem cells in regeneration. And its conclusion based on previous researches and trials, MSCs are considered effective therapy for testicular degeneration.
不育症是社会中一个严重的医学、经济和心理问题。男性因素不育症，由于精原细胞增殖和分化失败导致的生精功能障碍，似乎是 25-50%不育病例的原因。根据几项调查，睾丸退化可由多种物理、化学和微生物原因引起。干细胞是一种非特化细胞，其特征是通过有丝分裂细胞分裂进行自我更新，并能够分化为身体各种组织的特化细胞。这些数据是从不同的数据库（PubMed、Google Scholar、埃及知识库、Elsevier、Medline、Embase、ProQuest 和 BMC）中获取和分析的。本综述讨论了睾丸退化的原因、症状和分级，以及不同类型的干细胞在再生中的应用。并根据以前的研究和试验得出结论，间充质干细胞被认为是睾丸退化的有效治疗方法。
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