从蝎毒液中提取的生物活性肽：治疗支架和药理学工具。

Bioactive peptides from scorpion venoms: therapeutic scaffolds and pharmacological tools.

机构信息

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming 650107, China; Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.

Department of Reproductive Medicine, Affiliated Jinling Hospital, Nanjing Medical University, Nanjing 210002, China; Department of Gynecology, Womenapos;s Hospital of Nanjing Medical University, Nanjing 210004, China.

出版信息

Chin J Nat Med. 2023 Jan;21(1):19-35. doi: 10.1016/S1875-5364(23)60382-6.

DOI:10.1016/S1875-5364(23)60382-6

PMID:36641229

Abstract

Evolution and natural selection have endowed animal venoms, including scorpion venoms, with a wide range of pharmacological properties. Consequently, scorpions, their venoms, and/or their body parts have been used since time immemorial in traditional medicines, especially in Africa and Asia. With respect to their pharmacological potential, bioactive peptides from scorpion venoms have become an important source of scientific research. With the rapid increase in the characterization of various components from scorpion venoms, a large number of peptides are identified with an aim of combating a myriad of emerging global health problems. Moreover, some scorpion venom-derived peptides have been established as potential scaffolds helpful for drug development. In this review, we summarize the promising scorpion venoms-derived peptides as drug candidates. Accordingly, we highlight the data and knowledge needed for continuous characterization and development of additional natural peptides from scorpion venoms, as potential drugs that can treat related diseases.

摘要

进化和自然选择使动物毒液（包括蝎子毒液）具有广泛的药理学特性。因此，自古以来，蝎子、它们的毒液和/或身体部位就一直被用于传统药物中，尤其是在非洲和亚洲。就其药理学潜力而言，来自蝎子毒液的生物活性肽已成为科学研究的重要来源。随着对蝎子毒液中各种成分的快速特征描述，大量肽被鉴定出来，旨在应对各种新兴的全球健康问题。此外，一些蝎子毒液衍生肽已被确定为有助于药物开发的潜在支架。在这篇综述中，我们总结了有前途的蝎子毒液衍生肽作为候选药物。因此，我们强调了需要不断进行特征描述和开发来自蝎子毒液的额外天然肽的相关数据和知识，作为可以治疗相关疾病的潜在药物。