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探索冷大气等离子体在克服癌症耐药性方面的应用。

Exploring the Use of Cold Atmospheric Plasma to Overcome Drug Resistance in Cancer.

作者信息

Murillo Dzohara, Huergo Carmen, Gallego Borja, Rodríguez René, Tornín Juan

机构信息

Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.

Instituto Universitario de Oncología del Principado de Asturias, 33006 Oviedo, Spain.

出版信息

Biomedicines. 2023 Jan 14;11(1):208. doi: 10.3390/biomedicines11010208.

Abstract

Drug resistance is a major problem in cancer treatment, as it limits the effectiveness of pharmacological agents and can lead to disease progression. Cold atmospheric plasma (CAP) is a technology that uses ionized gas (plasma) to generate reactive oxygen and nitrogen species (RONS) that can kill cancer cells. CAP is a novel approach for overcoming drug resistance in cancer. In recent years, there has been a growing interest in using CAP to enhance the effectiveness of chemotherapy drugs. In this review, we discuss the mechanisms behind this phenomenon and explore its potential applications in cancer treatment. Going through the existing literature on CAP and drug resistance in cancer, we highlight the challenges and opportunities for further research in this field. Our review suggests that CAP could be a promising option for overcoming drug resistance in cancer and warrants further investigation.

摘要

耐药性是癌症治疗中的一个主要问题,因为它限制了药物制剂的有效性,并可能导致疾病进展。冷大气等离子体(CAP)是一种利用电离气体(等离子体)产生可杀死癌细胞的活性氧和氮物种(RONS)的技术。CAP是克服癌症耐药性的一种新方法。近年来,人们越来越有兴趣使用CAP来提高化疗药物的有效性。在这篇综述中,我们讨论了这一现象背后的机制,并探讨了其在癌症治疗中的潜在应用。通过查阅关于CAP和癌症耐药性的现有文献,我们强调了该领域进一步研究的挑战和机遇。我们的综述表明,CAP可能是克服癌症耐药性的一个有前景的选择,值得进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f191/9855365/d9f8d2decdc4/biomedicines-11-00208-g001.jpg

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