癌症免疫疗法的进展。
Advancements in Cancer Immunotherapies.
作者信息
Roy Ruchi, Singh Sunil Kumar, Misra Sweta
机构信息
UICentre for Drug Discovery, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.
Department of Surgery, University of Illinois at Chicago, Chicago, IL 60607, USA.
出版信息
Vaccines (Basel). 2022 Dec 27;11(1):59. doi: 10.3390/vaccines11010059.
Recent work has suggested involvement of the immune system in biological therapies specifically targeting tumor microenvironment. Substantial advancement in the treatment of malignant tumors utilizing immune cells, most importantly T cells that play a key role in cell-mediated immunity, have led to success in clinical trials. Therefore, this article focuses on the therapeutic approaches and developmental strategies to treat cancer. This review emphasizes the immunomodulatory response, the involvement of key tumor-infiltrating cells, the mechanistic aspects, and prognostic biomarkers. We also cover recent advancements in therapeutic strategies.
近期的研究表明，免疫系统参与了专门针对肿瘤微环境的生物疗法。利用免疫细胞，尤其是在细胞介导免疫中起关键作用的T细胞治疗恶性肿瘤取得了重大进展，并在临床试验中获得成功。因此，本文重点关注癌症的治疗方法和发展策略。本综述强调免疫调节反应、关键肿瘤浸润细胞的参与、作用机制以及预后生物标志物。我们还介绍了治疗策略的最新进展。
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