靶向蛋白降解技术与纳米医学：抗癌的强大盟友。
Targeted Protein Degradation Technology and Nanomedicine: Powerful Allies against Cancer.
机构信息
Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
出版信息
Small. 2023 May;19(18):e2207778. doi: 10.1002/smll.202207778. Epub 2023 Jan 24.
Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential of targeting undruggable pathogenic proteins. After the first proof-of-concept proteolysis-targeting chimeric (PROTAC) molecule was reported, the TPD field has entered a new era. In addition to PROTAC, numerous novel TPD strategies have emerged to expand the degradation landscape. However, their physicochemical properties and uncontrolled off-target side effects have limited their therapeutic efficacy, raising concerns regarding TPD delivery system. The combination of TPD and nanotechnology offers great promise in improving safety and therapeutic efficacy. This review provides an overview of novel TPD technologies, discusses their clinical applications, and highlights the trends and perspectives in TPD nanomedicine.
靶向蛋白降解（TPD）是一种新兴的治疗策略，具有靶向不可成药的致病蛋白的潜力。在首例概念验证的蛋白水解靶向嵌合体（PROTAC）分子被报道后，TPD 领域进入了一个新时代。除了 PROTAC，许多新的 TPD 策略已经出现，以扩大降解范围。然而，它们的物理化学性质和不可控的脱靶副作用限制了它们的治疗效果，引发了对 TPD 传递系统的担忧。TPD 和纳米技术的结合为提高安全性和治疗效果提供了巨大的前景。本文综述了新型 TPD 技术，讨论了它们的临床应用，并强调了 TPD 纳米医学的趋势和展望。
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