通过光声断层扫描监测新生儿脑出血进展。
Monitoring neonatal brain hemorrhage progression by photoacoustic tomography.
作者信息
Shan Tianqi, Yang Hao, Jiang Shixie, Jiang Huabei
机构信息
Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
出版信息
Biomed Opt Express. 2022 Dec 13;14(1):118-127. doi: 10.1364/BOE.469324. eCollection 2023 Jan 1.
Neonatal brain hemorrhage (NBH) is the most common neurological disorder in neonates and its clinical interventions are very limited. Understanding the pathology of NBH by non-invasive in-vivo characterization of standardized animal models is essential for developing potential treatments. Currently, there is no suitable tool to provide non-invasive, non-ionizing dynamic imaging of neonatal mouse models with high resolution, high contrast, and deep imaging depth. In this study, we implemented a fast 3D photoacoustic tomography (PAT) system suitable for imaging neonatal mouse brains with good image quality and demonstrated its feasibility in non-invasive monitoring of the dynamic process of NBH in the whole neonatal mouse brain. The results present a high resolution and sensitivity for NBH detection. Both morphological and hemodynamic changes of the hematoma were accurately obtained. Our results demonstrated the potential of PAT as a powerful tool for the preclinical study of neonatal brain hemorrhage.
新生儿脑出血（NBH）是新生儿最常见的神经系统疾病，其临床干预措施非常有限。通过标准化动物模型的非侵入性体内表征来了解NBH的病理学对于开发潜在治疗方法至关重要。目前，没有合适的工具能够对新生小鼠模型进行高分辨率、高对比度和深度成像的非侵入性、非电离动态成像。在本研究中，我们实现了一种适用于对新生小鼠大脑进行成像且图像质量良好的快速三维光声断层扫描（PAT）系统，并证明了其在非侵入性监测整个新生小鼠大脑NBH动态过程中的可行性。结果表明该系统对NBH检测具有高分辨率和高灵敏度。血肿的形态和血流动力学变化均被准确获取。我们的结果证明了PAT作为新生儿脑出血临床前研究有力工具的潜力。
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