伴或不伴鼻息肉的慢性鼻-鼻窦炎中的表观遗传修饰
Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps.
作者信息
Li Jing, Qiu Chang-Yu, Tao Yue-Jin, Cheng Lei
机构信息
Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Department of Otorhinolaryngology, The Affiliated Jiangning Hospital, Nanjing Medical University, Nanjing, China.
出版信息
Front Genet. 2023 Jan 9;13:1089647. doi: 10.3389/fgene.2022.1089647. eCollection 2022.
Chronic rhinosinusitis (CRS) has brought a huge socioeconomic burden. However, its mechanism is still elusive, which may involve genetic, environmental and some other factors. Epigenetic analyses have been conducted to explore the mechanisms underlying CRS. Here, we reviewed the fruits in the epigenetic studies on DNA methylation, histone modification, and non-coding RNA regulation. We concluded that the epigenetic research on CRS has made great breakthroughs, especially in the past 5 years and the field of microRNAs. "Epigenetic therapies" are expected to be designed to treat CRS in the future.
慢性鼻-鼻窦炎（CRS）已带来巨大的社会经济负担。然而，其发病机制仍不清楚，可能涉及遗传、环境和其他一些因素。目前已开展表观遗传学分析以探究CRS的潜在机制。在此，我们综述了DNA甲基化、组蛋白修饰和非编码RNA调控等表观遗传学研究成果。我们得出结论，CRS的表观遗传学研究已取得重大突破，尤其是在过去5年以及微小RNA领域。未来有望设计出“表观遗传疗法”来治疗CRS。
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