等离子体氧化钆纳米套娃：用于光热癌症治疗的双功能磁共振成像增强剂。
Plasmonic gadolinium oxide nanomatryoshkas: bifunctional magnetic resonance imaging enhancers for photothermal cancer therapy.
作者信息
Henderson Luke, Neumann Oara, Kadria-Vili Yara, Gerislioglu Burak, Bankson James, Nordlander Peter, Halas Naomi J
机构信息
Department of Chemistry, Rice University, 6100 Main St, Houston, TX 77005, USA.
Laboratory for Nanophotonics, Rice University, 6100 Main St, Houston, TX 77005, USA.
出版信息
PNAS Nexus. 2022 Jul 29;1(4):pgac140. doi: 10.1093/pnasnexus/pgac140. eCollection 2022 Sep.
Nanoparticle-assisted laser-induced photothermal therapy (PTT) is a promising method for cancer treatment; yet, visualization of nanoparticle uptake and photothermal response remain a critical challenge. Here, we report a magnetic resonance imaging-active nanomatryoshka (GdO-NM), a multilayered (Au core/GdO shell/Au shell) sub-100 nm nanoparticle capable of combining T MRI contrast with PTT. This bifunctional nanoparticle demonstrates an r of 1.28 × 10 mM s, an MRI contrast enhancement per nanoparticle sufficient for T imaging in addition to tumor ablation. GdO-NM also shows excellent stability in an acidic environment, retaining 99% of the internal Gd(3). This report details the synthesis and characterization of a promising system for combined theranostic nanoparticle tracking and PTT.
纳米粒子辅助激光诱导光热疗法（PTT）是一种很有前景的癌症治疗方法；然而，纳米粒子摄取和光热响应的可视化仍然是一个关键挑战。在此，我们报告了一种磁共振成像活性纳米套娃（GdO-NM），这是一种多层（金核/氧化钆壳/金壳）亚100纳米的纳米粒子，能够将T磁共振成像造影与PTT相结合。这种双功能纳米粒子的弛豫率为1.28×10 mM s，每个纳米粒子的磁共振成像造影增强足以用于T成像以及肿瘤消融。GdO-NM在酸性环境中也表现出出色的稳定性，保留了99%的内部Gd(3)。本报告详细介绍了一种用于联合治疗诊断纳米粒子追踪和PTT的有前景系统的合成与表征。
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