泌尿系统中的水通道蛋白

Aquaporins in Urinary System.

作者信息

Qiu Zhiwei, Jiang Tao, Li Yingjie, Wang Weiling, Yang Baoxue

机构信息

State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China.

College of Basic Medicine, Beihua University, Jilin, China.

出版信息

Adv Exp Med Biol. 2023;1398:155-177. doi: 10.1007/978-981-19-7415-1_11.

DOI:10.1007/978-981-19-7415-1_11

PMID:36717493

Abstract

There are at least eight aquaporins (AQPs) expressed in the kidney. Including AQP1 expressed in proximal tubules, thin descending limb of Henle and vasa recta; AQP2, AQP3, AQP4, AQP5, and AQP6 expressed in collecting ducts; AQP7 expressed in proximal tubules; AQP8 expressed in proximal tubules and collecting ducts; and AQP11 expressed in the endoplasmic reticulum of proximal tubular epithelial cells. Over years, researchers have constructed different AQP knockout mice and explored the effect of AQP knockout on kidney function. Thus, the roles of AQPs in renal physiology are revealed, providing very useful information for addressing fundamental questions about transepithelial water transport and the mechanism of near isoosmolar fluid reabsorption. This chapter introduces the localization and function of AQPs in the kidney and their roles in different kidney diseases to reveal the prospects of AQPs in further basic and clinical studies.

摘要

肾脏中至少表达八种水通道蛋白（AQP）。包括在近端小管、髓袢细降支和直小血管中表达的AQP1；在集合管中表达的AQP2、AQP3、AQP4、AQP5和AQP6；在近端小管中表达的AQP7；在近端小管和集合管中表达的AQP8；以及在近端肾小管上皮细胞内质网中表达的AQP11。多年来，研究人员构建了不同的AQP基因敲除小鼠，并探讨了AQP基因敲除对肾功能的影响。由此揭示了AQP在肾脏生理学中的作用，为解决跨上皮水转运和近等渗液体重吸收机制的基本问题提供了非常有用的信息。本章介绍了AQP在肾脏中的定位和功能及其在不同肾脏疾病中的作用，以揭示AQP在进一步基础和临床研究中的前景。