CTNNA1在恶性肿瘤中的作用：最新综述
The Role of CTNNA1 in Malignancies: An Updated Review.
作者信息
Huang Jinhua, Wang Huihui, Xu Yuting, Li Chunhua, Lv Xinyue, Han Xintong, Chen Xiaochun, Chen Yu, Yu Zhiying
机构信息
Department of Gynecology, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China.
College of Medicine, Shantou University, Shantou, 515041, Guangdong, China.
出版信息
J Cancer. 2023 Jan 1;14(2):219-230. doi: 10.7150/jca.79236. eCollection 2023.
Catenin alpha 1 (CTNNA1), encoding α-catenin, is involved in several physiological activities, such as adherens junction synthesis and signal transduction. Recent studies have suggested additional functions for CTNNA1 malignancies. This review systematically summarizes the varying functions of CTNNA1 in different tumors and briefly describes the diverse pathways and mechanisms involved in different types of tumors. CTNNA1 is abnormally expressed in leukemia and solid tumor such as cancers of digestive system, genitourinary system and breast, and it's related to the occurrence, development, and prognosis of tumors. In addition, the possible physiological processes involving CTNNA1, such as methylation, miRNA interference, or regulatory axes, similar to those of CDH1, SETD2, and hsa-miR-30d-5p/GJA1 are also summarized here. The precise mechanism of CTNNA1 in most cancers remains uncertain; hence, additional pre-clinical studies of CTNNA1 are warranted for potential early tumor diagnosis, prognosis, and treatment.
编码α-连环蛋白的连环蛋白α1（CTNNA1）参与多种生理活动，如黏附连接合成和信号转导。最近的研究表明CTNNA1在恶性肿瘤中还有其他功能。本综述系统总结了CTNNA1在不同肿瘤中的多种功能，并简要描述了不同类型肿瘤中涉及的多种途径和机制。CTNNA1在白血病和实体瘤（如消化系统、泌尿生殖系统和乳腺癌）中异常表达，并且它与肿瘤的发生、发展和预后相关。此外，本文还总结了可能涉及CTNNA1的生理过程，如甲基化、miRNA干扰或调控轴，类似于CDH1、SETD2和hsa-miR-30d-5p/GJA1的相关过程。CTNNA1在大多数癌症中的精确机制仍不确定；因此，有必要对CTNNA1进行更多的临床前研究，以用于潜在的早期肿瘤诊断、预后评估和治疗。
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