Department of Internal Medicine, Faculty of Medicine, Institute of Health, Jimma University, Jimma Ethiopia.
Department of Health Policy and Management, Faculty of Public Health, Institute of Health, Jimma University, Jimma Ethiopia.
Medicine (Baltimore). 2023 Feb 10;102(6):e31797. doi: 10.1097/MD.0000000000031797.
Anemia is a common complication of chronic kidney disease (CKD) and is associated with adverse patient outcomes. However, data on the prevalence of anemia in CKD patients is sparse, particularly in resource-limited settings. Therefore, this study aimed to assess the prevalence of anemia and its predictors among patients with CKD admitted to the Jimma medical center, southwest Ethiopia. A hospital-based prospective cross-sectional study was conducted from September 1 to November 30, 2020. All adult patients with CKD aged ≥18 years who fulfilled the inclusion criteria were consecutively recruited into the study. Data were entered into the Epi data manager version 4.4.1 and then exported to SPSS version 22 (IBM Corp., Armonk, NY) for analysis. The predictors of anemia were determined using multivariable logistic regression analysis. Statistical significance was set at P < .05. A total of 150 patients were included in this study. Of these, 64.67% were male, 56.67% had stage 5 CKD, 78% had a CKD duration of less than 1 year, and 74% had proteinuria. Hypertension (40.7%) and diabetes (14.7%) were the common causes of CKD. The prevalence of anemia was 85.33%. Of the patients, 28.67%, 40.67%, and 16% had mild, moderate, and severe anemia, respectively. On multivariate logistic regression, stage 4 CKD (adjusted odds ratio [AOR] 3.2, confidence interval [CI]: 1.78-12.91, P = .025), stage 5 CKD (AOR 4.03, CI: 1.17-13.73, P = .016), and CKD duration of less than 1 year (AOR 3, CI: 1.19-9.11, P = .007) were significantly associated with anemia. The prevalence of anemia among stage 3 to 5 CKD patients was very high. Anemia was significantly associated with the severity and duration of CKD. Therefore, serial follow-up of patients with a long duration and advanced stages of CKD may help prevent anemia and its adverse consequences.
贫血是慢性肾脏病(CKD)的常见并发症,与患者不良预后相关。然而,CKD 患者贫血患病率的数据很少,特别是在资源有限的环境中。因此,本研究旨在评估在埃塞俄比亚西南部的 Jimma 医疗中心接受治疗的 CKD 患者的贫血患病率及其预测因素。这是一项 2020 年 9 月 1 日至 11 月 30 日进行的基于医院的前瞻性横断面研究。所有符合纳入标准的年龄≥18 岁的 CKD 成年患者均连续纳入研究。数据输入 Epi Data 经理版本 4.4.1,然后导出到 SPSS 版本 22(IBM 公司,纽约州阿蒙克)进行分析。采用多变量逻辑回归分析确定贫血的预测因素。统计显著性设置为 P<0.05。本研究共纳入 150 例患者。其中,64.67%为男性,56.67%为 5 期 CKD,78%的 CKD 病程不到 1 年,74%有蛋白尿。高血压(40.7%)和糖尿病(14.7%)是 CKD 的常见病因。贫血的患病率为 85.33%。其中,28.67%、40.67%和 16%的患者分别有轻度、中度和重度贫血。在多变量逻辑回归中,4 期 CKD(调整后的优势比 [AOR] 3.2,置信区间 [CI]:1.78-12.91,P=0.025)、5 期 CKD(AOR 4.03,CI:1.17-13.73,P=0.016)和病程不足 1 年(AOR 3,CI:1.19-9.11,P=0.007)与贫血显著相关。3 期至 5 期 CKD 患者的贫血患病率非常高。贫血与 CKD 的严重程度和病程显著相关。因此,对病程长和晚期 CKD 患者进行连续随访可能有助于预防贫血及其不良后果。