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The potential role of opioid vaccines and monoclonal antibodies in the opioid overdose crisis.

作者信息

Martinez Suky, Harris Hannah, Chao Thomas, Luba Rachel, Pravetoni Marco, Comer Sandra D, Jones Jermaine D

机构信息

Division on Substance Use Disorders, Columbia University Irving Medical Center & New York State Psychiatric Institute, New York, NY, USA.

Behavioural Reward Affect + Impulsivity Neuroscience Lab, Faculty of Medicine, the University of British Columbia, Vancouver, Bc, Canada.

出版信息

Expert Opin Investig Drugs. 2023 Mar;32(3):181-185. doi: 10.1080/13543784.2023.2187286. Epub 2023 Mar 6.

Abstract
摘要

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本文引用的文献

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Improving Translational Research Outcomes for Opioid Use Disorder Treatments.
Curr Addict Rep. 2021 Mar;8(1):109-121. doi: 10.1007/s40429-020-00353-5. Epub 2021 Jan 12.
2
Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding.
Structure. 2023 Jan 5;31(1):20-32.e5. doi: 10.1016/j.str.2022.11.008. Epub 2022 Dec 12.
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Advancing humanized monoclonal antibody for counteracting fentanyl toxicity towards clinical development.
Hum Vaccin Immunother. 2022 Nov 30;18(6):2122507. doi: 10.1080/21645515.2022.2122507. Epub 2022 Oct 4.
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Unique Pharmacology, Brain Dysfunction, and Therapeutic Advancements for Fentanyl Misuse and Abuse.
Neurosci Bull. 2022 Nov;38(11):1365-1382. doi: 10.1007/s12264-022-00872-3. Epub 2022 May 15.
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Current status of vaccines for substance use disorders: A brief review of human studies.
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Trends in and Characteristics of Drug Overdose Deaths Involving Illicitly Manufactured Fentanyls - United States, 2019-2020.
MMWR Morb Mortal Wkly Rep. 2021 Dec 17;70(50):1740-1746. doi: 10.15585/mmwr.mm7050e3.
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A Highly Efficacious Carfentanil Vaccine That Blunts Opioid-Induced Antinociception and Respiratory Depression.
ACS Chem Biol. 2021 Feb 19;16(2):277-282. doi: 10.1021/acschembio.1c00026. Epub 2021 Feb 3.

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