农药对过氧化物酶体增殖物激活受体（PPARs）的影响及其与肥胖和糖尿病的关联。
Effect of Pesticides on Peroxisome Proliferator-Activated Receptors (PPARs) and Their Association with Obesity and Diabetes.
作者信息
Hernández-Valdez J, Velázquez-Zepeda A, Sánchez-Meza J C
机构信息
Facultad de Química, Universidad Autónoma del Estado de México. P. Colon S/N, Residencial Colon and Col Ciprés, Toluca de Lerdo 50120, Mexico.
出版信息
PPAR Res. 2023 Feb 24;2023:1743289. doi: 10.1155/2023/1743289. eCollection 2023.
Obesity and diabetes mellitus are considered the most important diseases of the XXI century. Recently, many epidemiological studies have linked exposure to pesticides to the development of obesity and type 2 diabetes mellitus. The role of pesticides and their possible influence on the development of these diseases was investigated by examining the relationship between these compounds and one of the major nuclear receptor families controlling lipid and carbohydrate metabolism: the peroxisome proliferator-activated receptors (PPARs), PPAR, PPAR/, and PPAR; this was possible through , , and assays. The present review aims to show the effect of pesticides on PPARs and their contribution to the changes in energy metabolism that enable the development of obesity and type 2 diabetes mellitus.
肥胖症和糖尿病被认为是21世纪最重要的疾病。最近，许多流行病学研究已将接触杀虫剂与肥胖症和2型糖尿病的发生联系起来。通过研究这些化合物与控制脂质和碳水化合物代谢的主要核受体家族之一：过氧化物酶体增殖物激活受体（PPARs）、PPARα、PPARβ/δ和PPARγ之间的关系，来研究杀虫剂的作用及其对这些疾病发生的可能影响；这可以通过[具体检测方法1]、[具体检测方法2]和[具体检测方法3]检测来实现。本综述旨在展示杀虫剂对PPARs的影响及其对能量代谢变化的作用，这些变化促使肥胖症和2型糖尿病的发生。
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