CD98hc-CD147 复合物在卵巢癌中的临床意义：一项生物信息学分析。
Clinical significance of the CD98hc-CD147 complex in ovarian cancer: a bioinformatics analysis.
机构信息
School of Stomatology, Jinzhou Medical University, Jinzhou, P.R. China.
Department of Gynaecology, Shenyang Women's and Children's Hospital, Shenyang, P.R. China.
出版信息
J Obstet Gynaecol. 2023 Dec;43(1):2188085. doi: 10.1080/01443615.2023.2188085.
Ovarian cancer is one of the most common malignant tumours affecting the female reproductive organs. CD147 (BSG) and CD98hc (SLC3A2) are oncogenes that form the CD98hc-CD147 complex, which regulates the proliferation, metastasis, metabolism, and cell cycle of cancer cells. The roles of the CD98hc-CD147 complex in ovarian cancer remain unclear. We analysed the expression and prognostic value of CD147 and CD98hc in ovarian cancer using the TCGA and ICGC databases. The effect of CD147 and CD98hc on the tumour immune response was analysed using the TIMER database. CD98hc was more highly expressed in normal tissues than primary tumour tissues, while CD147 was more highly expressed in primary tumour tissues than normal tissues. CD98hc expression was significantly associated with neutrophil and dendritic cell levels. CD147 and CD98hc were correlated with DNA repair, the cell cycle, and DNA replication. The CD98hc-CD147 complex could serve as a target for ovarian cancer treatment.
卵巢癌是最常见的女性生殖系统恶性肿瘤之一。CD147（BSG）和 CD98hc（SLC3A2）是形成 CD98hc-CD147 复合物的癌基因，该复合物调节癌细胞的增殖、转移、代谢和细胞周期。CD98hc-CD147 复合物在卵巢癌中的作用尚不清楚。我们使用 TCGA 和 ICGC 数据库分析了卵巢癌中 CD147 和 CD98hc 的表达和预后价值。使用 TIMER 数据库分析了 CD147 和 CD98hc 对肿瘤免疫反应的影响。CD98hc 在正常组织中的表达高于原发性肿瘤组织，而 CD147 在原发性肿瘤组织中的表达高于正常组织。CD98hc 的表达与中性粒细胞和树突状细胞水平显著相关。CD147 和 CD98hc 与 DNA 修复、细胞周期和 DNA 复制相关。CD98hc-CD147 复合物可以作为卵巢癌治疗的靶点。
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